Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells.
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ABSTRACT:
SUBMITTER: Mitchell DE
PROVIDER: S-EPMC4770432 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
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Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells.
Mitchell Daniel E DE Lovett Joseph R JR Armes Steven P SP Gibson Matthew I MI
Angewandte Chemie (International ed. in English) 20160128 8
The first fully synthetic polymer-based approach for red-blood-cell cryopreservation without the need for any (toxic) organic solvents is reported. Highly hydroxylated block copolymer worms are shown to be a suitable replacement for hydroxyethyl starch as a extracellular matrix for red blood cells. When used alone, the worms are not a particularly effective preservative. However, when combined with poly(vinyl alcohol), a known ice-recrystallization inhibitor, a remarkable additive cryopreservati ...[more]
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