Ontology highlight
ABSTRACT:
SUBMITTER: Singh N
PROVIDER: S-EPMC4770517 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Singh Nisha N Sharpley Ann L AL Emir Uzay E UE Masaki Charles C Herzallah Mohammad M MM Gluck Mark A MA Sharp Trevor T Harmer Catherine J CJ Vasudevan Sridhar R SR Cowen Philip J PJ Churchill Grant C GC
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20151123 7
Lithium remains the gold standard in treating bipolar disorder but has unwanted toxicity and side effects. We previously reported that ebselen inhibits inositol monophosphatase (IMPase) and exhibits lithium-like effects in animal models through lowering of inositol. Ebselen has been tested in clinical trials for other disorders, enabling us to determine for the first time the effect of a blood-brain barrier-penetrant IMPase inhibitor on human central nervous system (CNS) function. We now report ...[more]