Ontology highlight
ABSTRACT:
SUBMITTER: Feng L
PROVIDER: S-EPMC4770763 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Oncotarget 20151101 36
MicroRNAs (miRNAs) regulate disease-relevant metabolic pathways. However, most current pathway identification methods fail to consider miRNAs in addition to genes when analyzing pathways. We developed a powerful method called Subpathway-GMir to construct miRNA-regulated metabolic pathways and to identify miRNA-mediated subpathways by considering condition-specific genes, miRNAs, and pathway topologies. We used Subpathway-GMir to analyze two liver hepatocellular carcinomas (LIHC), one stomach ade ...[more]