Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.
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ABSTRACT:
SUBMITTER: Briata P
PROVIDER: S-EPMC4770880 | biostudies-literature | 2016 Mar-Apr
REPOSITORIES: biostudies-literature
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Diverse roles of the nucleic acid-binding protein KHSRP in cell differentiation and disease.
Briata Paola P Bordo Domenico D Puppo Margherita M Gorlero Franco F Rossi Martina M Perrone-Bizzozero Nora N Gherzi Roberto R
Wiley interdisciplinary reviews. RNA 20151227 2
The single-stranded nucleic acid-binding protein KHSRP (KH-type splicing regulatory protein) modulates RNA life and gene expression at various levels. KHSRP controls important cellular functions as different as proliferation, differentiation, metabolism, and response to infectious agents. We summarize and discuss experimental evidence providing a potential link between changes in KHSRP expression/function and human diseases including neuromuscular disorders, obesity, type II diabetes, and cancer ...[more]
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