Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior.

ABSTRACT: Motivation for reward drives adaptive behaviors, whereas impairment of reward perception and experience (anhedonia) can contribute to psychiatric diseases, including depression and schizophrenia. We sought to test the hypothesis that the medial prefrontal cortex (mPFC) controls interactions among specific subcortical regions that govern hedonic responses. By using optogenetic functional magnetic resonance imaging to locally manipulate but globally visualize neural activity in rats, we found that dopamine neuron stimulation drives striatal activity, whereas locally increased mPFC excitability reduces this striatal response and inhibits the behavioral drive for dopaminergic stimulation. This chronic mPFC overactivity also stably suppresses natural reward-motivated behaviors and induces speci

SUBMITTER: Ferenczi EA 

PROVIDER: S-EPMC4772156 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature