Dataset Information

Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase ?/?, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration.

ABSTRACT:

Background

Most classes of addictive substances alter the function and structural plasticity of the brain reward circuitry. Midkine (MK) and pleiotrophin (PTN) are growth/differentiation cytokines which, similarly to neurotrophins, play an important role in repair, neurite outgrowth, and cell differentiation. PTN or MK signaling through receptor protein tyrosine phosphatase ?/? (RPTP?/?), leads to the activation of extracellular signal-regulated kinases and thymoma viral proto-oncogene. This activation induces morphological changes and modulates addictive behaviors. Besides, there is increasing evidence that during the development of drug addiction, astrocytes contribute to the synaptic plasticity by synthesizing and releasing substances such as cytokines.

Methods

In the present work we studied the effect of acute morphine administration, chronic morphine administration, and morphine withdrawal on PTN, MK, and RPTP?/? expression and on their signaling pathways in the nucleus accumbens.

Results

Present results indicated that PTN, MK, and RPTP?/? levels increased after acute morphine injection, returned to basal levels during chronic opioid treatment, and were up-regulated again during morphine withdrawal. We also observed an activation of astrocytes after acute morphine injection and during opiate dependence and withdrawal. In addition, immunofluorescence analysis revealed that PTN, but not MK, was overexpressed in astrocytes and that dopaminoceptive neurons expressed RPTP?/?.

Conclusions

All these observations suggest that the neurotrophic and behavioral adaptations that occur during opiate addiction could be, at least partly, mediated by cytokines.

SUBMITTER: Garcia-Perez D

PROVIDER: S-EPMC4772269 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Publications

Regulation of Pleiotrophin, Midkine, Receptor Protein Tyrosine Phosphatase β/ζ, and Their Intracellular Signaling Cascades in the Nucleus Accumbens During Opiate Administration.

García-Pérez Daniel D Laorden María Luisa ML Milanés María Victoria MV

The international journal of neuropsychopharmacology 20150711 1

<h4>Background</h4>Most classes of addictive substances alter the function and structural plasticity of the brain reward circuitry. Midkine (MK) and pleiotrophin (PTN) are growth/differentiation cytokines which, similarly to neurotrophins, play an important role in repair, neurite outgrowth, and cell differentiation. PTN or MK signaling through receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ), leads to the activation of extracellular signal-regulated kinases and thymoma viral proto-oncogene. ...[more]

PMID: 26164717

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