Ontology highlight
ABSTRACT:
SUBMITTER: Bernardo BC
PROVIDER: S-EPMC4772383 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Bernardo Bianca C BC Nguyen Sally S SS Gao Xiao-Ming XM Tham Yow Keat YK Ooi Jenny Y Y JY Patterson Natalie L NL Kiriazis Helen H Su Yidan Y Thomas Colleen J CJ Lin Ruby C Y RC Du Xiao-Jun XJ McMullen Julie R JR
Scientific reports 20160301
Expression of miR-154 is upregulated in the diseased heart and was previously shown to be upregulated in the lungs of patients with pulmonary fibrosis. However, the role of miR-154 in a model of sustained pressure overload-induced cardiac hypertrophy and fibrosis had not been assessed. To examine the role of miR-154 in the diseased heart, adult male mice were subjected to transverse aortic constriction for four weeks, and echocardiography was performed to confirm left ventricular hypertrophy and ...[more]