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An Event-Related Potential Study on the Effects of Cannabis on Emotion Processing.

ABSTRACT: The effect of cannabis on emotional processing was investigated using event-related potential paradigms (ERPs). ERPs associated with emotional processing of cannabis users, and non-using controls, were recorded and compared during an implicit and explicit emotional expression recognition and empathy task. Comparisons in P3 component mean amplitudes were made between cannabis users and controls. Results showed a significant decrease in the P3 amplitude in cannabis users compared to controls. Specifically, cannabis users showed reduced P3 amplitudes for implicit compared to explicit processing over centro-parietal sites which reversed, and was enhanced, at fronto-central sites. Cannabis users also showed a decreased P3 to happy faces, with an increase to angry faces, compared to controls. These effects appear to increase with those participants that self-reported the highest levels of cannabis consumption. Those cannabis users with the greatest consumption rates showed the largest P3 deficits for explicit processing and negative emotions. These data suggest that there is a complex relationship between cannabis consumption and emotion processing that appears to be modulated by attention.

SUBMITTER: Troup LJ

PROVIDER: S-EPMC4772908 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature

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An Event-Related Potential Study on the Effects of Cannabis on Emotion Processing.

Troup Lucy J LJ Bastidas Stephanie S Nguyen Maia T MT Andrzejewski Jeremy A JA Bowers Matthew M Nomi Jason S JS

PloS one 20160229 2

The effect of cannabis on emotional processing was investigated using event-related potential paradigms (ERPs). ERPs associated with emotional processing of cannabis users, and non-using controls, were recorded and compared during an implicit and explicit emotional expression recognition and empathy task. Comparisons in P3 component mean amplitudes were made between cannabis users and controls. Results showed a significant decrease in the P3 amplitude in cannabis users compared to controls. Spec ...[more]

PMID: 26926868

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Project description:Self-referential emotion refers to the process of evaluating emotional stimuli with respect to the self. Processes indicative of a self-positivity bias are reflected in electroencephalogram (EEG) signals at ~400 ms when the task does not require a discrimination of self from other. However, when distinguishing between self-referential and other-referential emotions is required, previous studies have shown inconsistent temporal dynamics of EEG signals in slightly different tasks. Based on the observation of early self-other discrimination, we hypothesized that self would be rapidly activated in the early stage to modulate emotional processing in the late stage during an implicit self-referential emotion. To test this hypothesis, we employed an implicit task in which participants were asked to judge the order of Chinese characters of trait adjectives preceded by a self ("I") or other pronoun ("He" or "She"). This study aimed to explore the difference of social-related emotional evaluation from self-reference; the other pronoun was not defined to a specific person, rather it referred to the general concept. Sixteen healthy Chinese subjects participated in the experiment. Event-related potentials (ERPs) showed that there were self-other discrimination effects in the N1 (80-110 ms) and P1 (170-200 ms) components in the anterior brain. The emotional valence was discriminated in the later component of N2 (220-250 ms). The interaction between self-reference and emotional valence occurred during the late positive potential (LPP; 400-500 ms). Moreover, there was a positive correlation between response time (RT) and N1 in the self-reference condition based on the positive-negative contrast, suggesting a modulatory effect of the self-positivity bias. The results indicate that self-reference emerges earlier than emotion and then combines with emotional processing in an implicit task. The findings extend the view that the self plays a highly integrated and modulated role in self-referential emotion processing.

Project description:IntroductionDyscalculia is a specific learning disorder affecting the ability to learn certain math processes, such as arithmetic data recovery. The group of children with dyscalculia is very heterogeneous, in part due to variability in their working memory (WM) deficits. To assess the brain response to arithmetic data recovery, we applied an arithmetic verification task during an event-related potential (ERP) recording. Two effects have been reported: the N400 effect (higher negative amplitude for incongruent than for congruent condition), associated with arithmetic incongruency and caused by the arithmetic priming effect, and the LPC effect (higher positive amplitude for the incongruent compared to the congruent condition), associated with a reevaluation process and modulated by the plausibility of the presented condition. This study aimed to (a) compare arithmetic processing between children with dyscalculia and children with good academic performance (GAP) using ERPs during an addition verification task and (b) explore, among children with dyscalculia, the relationship between WM and ERP effects.Materials and methodsEEGs of 22 children with dyscalculia (DYS group) and 22 children with GAP (GAP group) were recorded during the performance of an addition verification task. ERPs synchronized with the probe stimulus were computed separately for the congruent and incongruent probes, and included only epochs with correct answers. Mixed 2-way ANOVAs for response times and correct answers were conducted. Comparisons between groups and correlation analyses using ERP amplitude data were carried out through multivariate nonparametric permutation tests.ResultsThe GAP group obtained more correct answers than the DYS group. An arithmetic N400 effect was observed in the GAP group but not in the DYS group. Both groups displayed an LPC effect. The larger the LPC amplitude was, the higher the WM index. Two subgroups were found within the DYS group: one with an average WM index and the other with a lower than average WM index. These subgroups displayed different ERPs patterns.DiscussionThe results indicated that the group of children with dyscalculia was very heterogeneous and therefore failed to show a robust LPC effect. Some of these children had WM deficits. When WM deficits were considered together with dyscalculia, an atypical ERP pattern that reflected their processing difficulties emerged. Their lack of the arithmetic N400 effect suggested that the processing in this step was not useful enough to produce an answer; thus, it was necessary to reevaluate the arithmetic-calculation process (LPC) in order to deliver a correct answer.ConclusionGiven that dyscalculia is a very heterogeneous deficit, studies examining dyscalculia should consider exploring deficits in WM because the whole group of children with dyscalculia seems to contain at least two subpopulations that differ in their calculation process.

Dataset Information

An Event-Related Potential Study on the Effects of Cannabis on Emotion Processing.

Publications

An Event-Related Potential Study on the Effects of Cannabis on Emotion Processing.

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