Reduction in mitochondrial iron alleviates cardiac damage during injury.
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ABSTRACT:
SUBMITTER: Chang HC
PROVIDER: S-EPMC4772952 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
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Reduction in mitochondrial iron alleviates cardiac damage during injury.
Chang Hsiang-Chun HC Wu Rongxue R Shang Meng M Sato Tatsuya T Chen Chunlei C Shapiro Jason S JS Liu Ting T Thakur Anita A Sawicki Konrad T KT Prasad Sathyamangla V N SV Ardehali Hossein H
EMBO molecular medicine 20160301 3
Excess cellular iron increases reactive oxygen species (ROS) production and causes cellular damage. Mitochondria are the major site of iron metabolism and ROS production; however, few studies have investigated the role of mitochondrial iron in the development of cardiac disorders, such as ischemic heart disease or cardiomyopathy (CM). We observe increased mitochondrial iron in mice after ischemia/reperfusion (I/R) and in human hearts with ischemic CM, and hypothesize that decreasing mitochondria ...[more]
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