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Impact of the ?-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between ? adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study.


ABSTRACT: We evaluated the association between coding region variants of adrenergic receptor genes and therapeutic effect in patients with congestive heart failure (CHF).One hundred patients with stable CHF (left ventricular ejection fraction [LVEF] < 45%) were enrolled. Enrolled patients started 1.25 mg bisoprolol treatment once daily, then up-titrated to the maximally tolerable dose, at which they were treated for 1 year.Genotypic analysis was carried out, but the results were blinded to the investigators throughout the study period. At position 389 of the ?-1 adrenergic receptor gene (ADRB1), the observed minor Gly allele frequency (Gly389Arg + Gly389Gly) was 0.21, and no deviation from Hardy-Weinberg equilibrium was observed in the genotypic distribution of Arg389Gly (p = 0.75). Heart rate was reduced from 80.8 ± 14.3 to 70.0 ± 15.0 beats per minute (p < 0.0001). There was no significant difference in final heart rate across genotypes. However, the Arg389Arg genotype group required significantly more bisoprolol compared to the Gly389X (Gly389Arg + Gly389Gly) group (5.26 ± 2.62 mg vs. 3.96 ± 2.05 mg, p = 0.022). There were no significant differences in LVEF changes or remodeling between two groups. Also, changes in exercise capacity and brain natriuretic peptide level were not significant. However, interestingly, there was a two-fold higher rate of readmission (21.2% vs. 10.0%, p = 0.162) and one CHF-related death in the Arg389Arg group.The ADRB1 Gly389X genotype showed greater response to bisoprolol than the Arg389Arg genotype, suggesting the potential of individually tailoring ?-blocker therapy according to genotype.

SUBMITTER: Lee HY 

PROVIDER: S-EPMC4773723 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Impact of the β-1 adrenergic receptor polymorphism on tolerability and efficacy of bisoprolol therapy in Korean heart failure patients: association between β adrenergic receptor polymorphism and bisoprolol therapy in heart failure (ABBA) study.

Lee Hae-Young HY   Chung Wook-Jin WJ   Jeon Hui-Kyung HK   Seo Hong-Seog HS   Choi Dong-Ju DJ   Jeon Eun-Seok ES   Kim Jae-Joong JJ   Shin Joon Han JH   Kang Seok-Min SM   Lim Sung Cil SC   Baek Sang-Hong SH  

The Korean journal of internal medicine 20160216 2


<h4>Background/aims</h4>We evaluated the association between coding region variants of adrenergic receptor genes and therapeutic effect in patients with congestive heart failure (CHF).<h4>Methods</h4>One hundred patients with stable CHF (left ventricular ejection fraction [LVEF] < 45%) were enrolled. Enrolled patients started 1.25 mg bisoprolol treatment once daily, then up-titrated to the maximally tolerable dose, at which they were treated for 1 year.<h4>Results</h4>Genotypic analysis was carr  ...[more]

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