Ontology highlight
ABSTRACT:
SUBMITTER: Velenosi TJ
PROVIDER: S-EPMC4773761 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Velenosi Thomas J TJ Hennop Anzel A Feere David A DA Tieu Alvin A Kucey Andrew S AS Kyriacou Polydoros P McCuaig Laura E LE Nevison Stephanie E SE Kerr Michael A MA Urquhart Bradley L BL
Scientific reports 20160302
Chronic kidney disease (CKD) results in the accumulation of metabolic waste products that are normally cleared by the kidney, known as uremia. Many of these waste products are from bacteria metabolites in the gut. Accumulation of uremic toxins in plasma and tissue, as well as the gut-plasma-tissue metabolic axis are important for understanding pathophysiological mechanisms of comorbidities in CKD. In this study, an untargeted metabolomics approach was used to determine uremic toxin accumulation ...[more]