Ontology highlight
ABSTRACT:
SUBMITTER: Hidajat R
PROVIDER: S-EPMC4773897 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Hidajat Rachmat R Nickols Brian B Forrester Naomi N Tretyakova Irina I Weaver Scott S Pushko Peter P
Virology 20160206
Chikungunya virus (CHIKV) represents a pandemic threat with no approved vaccine available. Recently, we described a novel vaccination strategy based on iDNA® infectious clone designed to launch a live-attenuated CHIKV vaccine from plasmid DNA in vitro or in vivo. As a proof of concept, we prepared iDNA plasmid pCHIKV-7 encoding the full-length cDNA of the 181/25 vaccine. The DNA-launched CHIKV-7 virus was prepared and compared to the 181/25 virus. Illumina HiSeq2000 sequencing revealed that with ...[more]