Ontology highlight
ABSTRACT:
SUBMITTER: Promponas VJ
PROVIDER: S-EPMC4773986 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Promponas Vasilis J VJ Katsani Katerina R KR Blencowe Benjamin J BJ Ouzounis Christos A CA
Scientific reports 20160302
Eukaryotic cells are defined by compartments through which the trafficking of macromolecules is mediated by large complexes, such as the nuclear pore, transport vesicles and intraflagellar transport. The assembly and maintenance of these complexes is facilitated by endomembrane coatomers, long suspected to be divergently related on the basis of structural and more recently phylogenomic analysis. By performing supervised walks in sequence space across coatomer superfamilies, we uncover subtle seq ...[more]