Ontology highlight
ABSTRACT:
SUBMITTER: Zou L
PROVIDER: S-EPMC4774874 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Acta crystallographica. Section F, Structural biology communications 20160216 Pt 3
Serine racemase (SR) is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that is responsible for D-serine biosynthesis in vivo. The first X-ray crystal structure of maize SR was determined to 2.1 Å resolution and PLP binding was confirmed in solution by UV-Vis absorption spectrometry. Maize SR belongs to the type II PLP-dependent enzymes and differs from the SR of a vancomycin-resistant bacterium. The PLP is bound to each monomer by forming a Schiff base with Lys67. Structural comparison with rat ...[more]