Ontology highlight
ABSTRACT:
SUBMITTER: Reznik E
PROVIDER: S-EPMC4775221 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Reznik Ed E Miller Martin L ML Şenbabaoğlu Yasin Y Riaz Nadeem N Sarungbam Judy J Tickoo Satish K SK Al-Ahmadie Hikmat A HA Lee William W Seshan Venkatraman E VE Hakimi A Ari AA Sander Chris C
eLife 20160222
Mutations, deletions, and changes in copy number of mitochondrial DNA (mtDNA), are observed throughout cancers. Here, we survey mtDNA copy number variation across 22 tumor types profiled by The Cancer Genome Atlas project. We observe a tendency for some cancers, especially of the bladder, breast, and kidney, to be depleted of mtDNA, relative to matched normal tissue. Analysis of genetic context reveals an association between incidence of several somatic alterations, including IDH1 mutations in g ...[more]