An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor.
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ABSTRACT:
SUBMITTER: Dagdas YF
PROVIDER: S-EPMC4775223 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor.
Dagdas Yasin F YF Belhaj Khaoula K Maqbool Abbas A Chaparro-Garcia Angela A Pandey Pooja P Petre Benjamin B Tabassum Nadra N Cruz-Mireles Neftaly N Hughes Richard K RK Sklenar Jan J Win Joe J Menke Frank F Findlay Kim K Banfield Mark J MJ Kamoun Sophien S Bozkurt Tolga O TO
eLife 20160114
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has ...[more]
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Project description:Responsible for the Irish potato famine of 1845-49, the oomycete pathogen Phytophthora infestans caused persistent, devastating outbreaks of potato late blight across Europe in the 19th century. Despite continued interest in the history and spread of the pathogen, the genome of the famine-era strain remains entirely unknown. Here we characterize temporal genomic changes in introduced P. infestans. We shotgun sequence five 19th-century European strains from archival herbarium samples--including the oldest known European specimen, collected in 1845 from the first reported source of introduction. We then compare their genomes to those of extant isolates. We report multiple distinct genotypes in historical Europe and a suite of infection-related genes different from modern strains. At virulence-related loci, several now-ubiquitous genotypes were absent from the historical gene pool. At least one of these genotypes encodes a virulent phenotype in modern strains, which helps explain the 20th century's episodic replacements of European P. infestans lineages.
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