An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor.
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ABSTRACT:
SUBMITTER: Dagdas YF
PROVIDER: S-EPMC4775223 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor.
Dagdas Yasin F YF Belhaj Khaoula K Maqbool Abbas A Chaparro-Garcia Angela A Pandey Pooja P Petre Benjamin B Tabassum Nadra N Cruz-Mireles Neftaly N Hughes Richard K RK Sklenar Jan J Win Joe J Menke Frank F Findlay Kim K Banfield Mark J MJ Kamoun Sophien S Bozkurt Tolga O TO
eLife 20160114
Plants use autophagy to safeguard against infectious diseases. However, how plant pathogens interfere with autophagy-related processes is unknown. Here, we show that PexRD54, an effector from the Irish potato famine pathogen Phytophthora infestans, binds host autophagy protein ATG8CL to stimulate autophagosome formation. PexRD54 depletes the autophagy cargo receptor Joka2 out of ATG8CL complexes and interferes with Joka2's positive effect on pathogen defense. Thus, a plant pathogen effector has ...[more]
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