Ontology highlight
ABSTRACT:
SUBMITTER: Lim SO
PROVIDER: S-EPMC4775355 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Lim Seung-Oe SO Li Chia-Wei CW Xia Weiya W Lee Heng-Huan HH Chang Shih-Shin SS Shen Jia J Hsu Jennifer L JL Raftery Daniel D Djukovic Danijel D Gu Haiwei H Chang Wei-Chao WC Wang Hung-Ling HL Chen Mong-Liang ML Huo Longfei L Chen Chung-Hsuan CH Wu Yun Y Sahin Aysegul A Hanash Samir M SM Hortobagyi Gabriel N GN Hung Mien-Chie MC
Cancer research 20160112 5
Oncogenic signaling reprograms cancer cell metabolism to augment the production of glycolytic metabolites in favor of tumor growth. The ability of cancer cells to evade immunosurveillance and the role of metabolic regulators in T-cell functions suggest that oncogene-induced metabolic reprogramming may be linked to immune escape. EGF signaling, frequently dysregulated in triple-negative breast cancer (TNBC), is also associated with increased glycolysis. Here, we demonstrated in TNBC cells that EG ...[more]