Colistin-Resistant Acinetobacter baumannii Clinical Strains with Deficient Biofilm Formation.
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SUBMITTER: Dafopoulou K
PROVIDER: S-EPMC4776000 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
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Colistin-Resistant Acinetobacter baumannii Clinical Strains with Deficient Biofilm Formation.
Dafopoulou Konstantina K Xavier Basil Britto BB Hotterbeekx An A Janssens Lore L Lammens Christine C Dé Emmanuelle E Goossens Herman H Tsakris Athanasios A Malhotra-Kumar Surbhi S Pournaras Spyros S
Antimicrobial agents and chemotherapy 20151214 3
In two pairs of clinical colistin-susceptible/colistin-resistant (Cst(s)/Cst(r)) Acinetobacter baumannii strains, the Cst(r) strains showed significantly decreased biofilm formation in static and dynamic assays (P < 0.001) and lower relative fitness (P < 0.05) compared with those of the Cst(s) counterparts. The whole-genome sequencing comparison of strain pairs identified a mutation converting a stop codon to lysine (*241K) in LpsB (involved in lipopolysaccharide [LPS] synthesis) in one Cst(r) s ...[more]
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