Ontology highlight
ABSTRACT:
SUBMITTER: Drsata T
PROVIDER: S-EPMC4776040 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Dršata Tomáš T Zgarbová Marie M Jurečka Petr P Šponer Jiří J Lankaš Filip F
Biophysical journal 20160127 4
A recent study described an allosteric effect in which the binding of a protein to DNA is influenced by another protein bound nearby. The effect shows a periodicity of ∼10 basepairs and decays with increasing protein-protein distance. As a mechanistic explanation, the authors reported a similar periodic, decaying pattern of the correlation coefficient between major groove widths inferred from a shorter molecular dynamics simulation. Here we show that in a state-of-the-art, microsecond-long simul ...[more]