Ontology highlight
ABSTRACT:
SUBMITTER: Bruinsma BG
PROVIDER: S-EPMC4776101 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Bruinsma Bote G BG Sridharan Gautham V GV Weeder Pepijn D PD Avruch James H JH Saeidi Nima N Özer Sinan S Geerts Sharon S Porte Robert J RJ Heger Michal M van Gulik Thomas M TM Martins Paulo N PN Markmann James F JF Yeh Heidi H Uygun Korkut K
Scientific reports 20160303
As donor organ shortages persist, functional machine perfusion is under investigation to improve preservation of the donor liver. The transplantation of donation after circulatory death (DCD) livers is limited by poor outcomes, but its application may be expanded by ex vivo repair and assessment of the organ before transplantation. Here we employed subnormothermic (21 °C) machine perfusion of discarded human livers combined with metabolomics to gain insight into metabolic recovery during machine ...[more]