Ontology highlight
ABSTRACT:
SUBMITTER: Yan J
PROVIDER: S-EPMC4776158 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Yan Jingyi J Dong Jianing J Wu Jiaxin J Zhu Rui R Wang Zhen Z Wang Baoming B Wang Lizheng L Wang Zixuan Z Zhang Haihong H Wu Hui H Yu Bin B Kong Wei W Yu Xianghui X
Scientific reports 20160303
The immunogenicity of recombinant adenovirus serotype 5 (rAd5) vectors has been shown to be suppressed by neutralizing antibodies (NAbs) directed primarily against hexon hypervariable regions (HVRs). Preexisting immunity can be circumvented by replacing HVRs of rAd5 hexon with those derived from alternate adenovirus serotypes. However, chimeric modification of rAd5 hexon HVRs tends to cause low packaging efficiency or low proliferation of rAd5 vectors, but the related mechanism remains unclear. ...[more]