Dataset Information

Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.

ABSTRACT: The association between maternal cadmium (Cd) exposure during pregnancy and the increased risk of fetal growth restriction (FGR) remains controversial. The present study evaluated the association between maternal serum Cd level and risk of small for gestational age (SGA) infants in a Chinese population. The present study analyzed a subsample of the C-ABCS cohort that recruited 3254 eligible mother-and-singleton-offspring pairs. Maternal serum Cd level during pregnancy was measured by graphite furnace atomic absorption spectrometry. The rate and odds ratio (OR) for SGA infant were calculated. The rate for SGA infant was 10.6% among subjects with H-Cd (?1.06??g/L), significantly higher than 7.5% among subjects with L-Cd (<1.06??g/L). OR was 1.45 (95% CI: 1.11, 1.90; P?=?0.007) among subjects with H-Cd. Adjusted OR for SGA infants was 1.43 (95% CI: 1.09, 1.88; P?=?0.007) among subjects with H-Cd. Taken together, we observe the fact that maternal Cd exposure at middle gestational stage, elevates the risk of SGA in contrast to early gestational stage. The present results might be interesting and worth more discussing, and guarantee to further studies.

SUBMITTER: Wang H

PROVIDER: S-EPMC4776171 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.

Wang Hua H Liu Lu L Hu Yong-Fang YF Hao Jia-Hu JH Chen Yuan-Hua YH Su Pu-Yu PY Fu Lin L Yu Zhen Z Zhang Gui-Bin GB Wang Lei L Tao Fang-Biao FB Xu De-Xiang DX

Scientific reports 20160303

The association between maternal cadmium (Cd) exposure during pregnancy and the increased risk of fetal growth restriction (FGR) remains controversial. The present study evaluated the association between maternal serum Cd level and risk of small for gestational age (SGA) infants in a Chinese population. The present study analyzed a subsample of the C-ABCS cohort that recruited 3254 eligible mother-and-singleton-offspring pairs. Maternal serum Cd level during pregnancy was measured by graphite fu ...[more]

PMID: 26934860

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Project description:BackgroundOxidative stress in preeclampsia and small for gestational age (SGA) birth suggests antioxidant supplementation could prevent these conditions. However, it remains unclear whether maternal antioxidant levels are systematically lower in these pregnancies.ObjectiveTo conduct a systematic review of the association between maternal antioxidant levels during pregnancy and preeclampsia or SGA.MethodsWe searched PubMed, Embase, and several other databases from 1970-2013 for observational studies that measured maternal blood levels of non-enzymatic antioxidants (vitamins A, C, E, and carotenoids) during pregnancy or within 72 hours of delivery. The entire review process was done in duplicate. Study quality was assessed using the Newcastle-Ottawa Scale and additional questions. We pooled the standardized mean difference (SMD) across studies, stratified by outcome and pregnancy trimester, and investigated heterogeneity using meta-regression.ResultsWe reviewed 1,882 unique citations and 64 studies were included. Most studies were small with important risk of bias. Among studies that addressed preeclampsia (n = 58) and SGA (n = 9), 16% and 66%, respectively, measured levels prior to diagnosis. The SMDs for vitamins A, C, and E were significantly negative for overall preeclampsia, but not for mild or severe preeclampsia subtypes. Significant heterogeneity was observed in all meta-analyses and most could not be explained. Evidence for lower carotenoid antioxidants in preeclampsia and SGA was limited and inconclusive. Publication bias appears likely.ConclusionsSmall, low-quality studies limit conclusions that can be drawn from the available literature. Observational studies inconsistently show that vitamins C and E or other antioxidants are lower in women who develop preeclampsia or SGA. Reverse causality remains a possible explanation for associations observed. New clinical trials are not warranted in light of this evidence; however, additional rigorous observational studies measuring antioxidant levels before clinical detection of preeclampsia and SGA may clarify whether levels are altered at a causally-relevant time of pregnancy.

Dataset Information

Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.

Publications

Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.

Similar Datasets

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