LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels.
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ABSTRACT:
SUBMITTER: Jimenez-Torres JA
PROVIDER: S-EPMC4776323 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Publications
LumeNEXT: A Practical Method to Pattern Luminal Structures in ECM Gels.
Jiménez-Torres José A JA Peery Stephen L SL Sung Kyung E KE Beebe David J DJ
Advanced healthcare materials 20151126 2
In vitro biomimetic modeling of physio-logical structures bridges the gap between 2D in vitro culture and animal models. Lumens (tubular structures) are ubiquitous in vivo, being present in blood vessels, mammary ducts, and the lymphatic system. A method 'LumeNEXT' is presented here that allows the fabrication of 3D embedded lumens where size, structure, distance, and configuration can be controlled using standard poly-dimethylsiloxane micromolding methods. ...[more]
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