Dataset Information

Chronic widespread pain is associated with worsening frailty in European men.

ABSTRACT:

Background

we hypothesised that chronic widespread pain (CWP), by acting as a potential stressor, may predispose to the development of, or worsening, frailty.

Setting

longitudinal analysis within the European Male Ageing Study (EMAS).

Participants

a total of 2,736 community-dwelling men aged 40-79.

Methods

subjects completed a pain questionnaire and shaded a manikin, with the presence of CWP defined using the American College of Rheumatology criteria. Physical activity, smoking, alcohol consumption and depression were measured. Repeat assessments took place a median of 4.3 years later. A frailty index (FI) was used, with frail defined as an FI >0.35. The association between CWP at baseline and the new occurrence of frailty was examined using logistic regression; the association between CWP at baseline and change in FI was examined using negative binomial regression.

Results

at baseline, 218 (8.3%) men reported CWP. Of the 2,631 men who were defined as non-frail at baseline, 112 (4.3%) were frail at follow-up; their mean FI was 0.12 (SD 0.1) at baseline and 0.15 (SD 0.1) at follow-up, with a mean change of 0.03 (SD 0.08) P ? 0.001. Among men who were non-frail at baseline, those with CWP were significantly more likely to develop frailty. After adjustment for age and centre, compared with those with no pain, those with CWP at baseline had a 70% higher FI at follow-up; these associations remained significant after further adjustment for smoking, body mass index, depression, physical activity and FI at baseline.

Conclusion

the presence of CWP is associated with an increased risk of frailty in older European men.

SUBMITTER: Wade KF

PROVIDER: S-EPMC4776622 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Publications

Chronic widespread pain is associated with worsening frailty in European men.

Wade Katie Fredrika KF Lee David M DM McBeth John J Ravindrarajah Rathi R Gielen Evelien E Pye Stephen R SR Vanderschueren Dirk D Pendleton Neil N Finn Joseph D JD Bartfai György G Casanueva Felipe F FF Forti Gianni G Giwercman Aleksander A Huhtaniemi Ilpo T IT Kula Krzysztof K Punab Margus M Wu Frederick C W FC O'Neill Terence W TW

Age and ageing 20151217 2

<h4>Background</h4>we hypothesised that chronic widespread pain (CWP), by acting as a potential stressor, may predispose to the development of, or worsening, frailty.<h4>Setting</h4>longitudinal analysis within the European Male Ageing Study (EMAS).<h4>Participants</h4>a total of 2,736 community-dwelling men aged 40-79.<h4>Methods</h4>subjects completed a pain questionnaire and shaded a manikin, with the presence of CWP defined using the American College of Rheumatology criteria. Physical activi ...[more]

PMID: 26679698

Similar Datasets

Project description:BackgroundChronic postsurgical pain (CPSP) is a clinical problem, and large prospective studies are needed to determine its incidence, characteristics, and risk factors.ObjectiveTo find predictive factors for CPSP in an international survey.DesignObservational study.SettingMulticentre European prospective observational trial.PatientsPatients undergoing breast cancer surgery, sternotomy, endometriosis surgery, or total knee arthroplasty (TKA).MethodStandardised questionnaires were completed by the patients at 1, 3, and 7 days, and at 1, 3, and 6 months after surgery, with follow-up via E-mail, telephone, or interview.Main outcome measureThe primary goal of NIT-1 was to propose a scoring system to predict those patient likely to have CPSP at 6 months after surgery.ResultsA total of 3297 patients were included from 18 hospitals across Europe and 2494 patients were followed-up for 6 months. The mean incidence of CPSP at 6 months was 10.5%, with variations depending on the type of surgery: sternotomy 6.9%, breast surgery 7.4%, TKA 12.9%, endometriosis 16.2%. At 6 months, neuropathic characteristics were frequent for all types of surgery: sternotomy 33.3%, breast surgery 67.6%, TKA 42.4%, endometriosis 41.4%. One-third of patients experienced CPSP at both 3 and 6 months. Pre-operative pain was frequent for TKA (leg pain) and endometriosis (abdomen) and its frequency and intensity were reduced after surgery. Severe CPSP and a neuropathic pain component decreased psychological and functional wellbeing as well as quality of life. No overarching CPSP risk factors were identified.ConclusionUnfortunately, our findings do not offer a new CPSP predictive score. However, we present reliable new data on the incidence, characteristics, and consequences of CPSP from a large European survey. Interesting new data on the time course of CPSP, its neuropathic pain component, and CPSP after endometriosis surgery generate new hypotheses but need to be confirmed by further research.Trial registrationclinicaltrials.gov ID: NCT03834922.

Dataset Information

Chronic widespread pain is associated with worsening frailty in European men.

Background

Setting

Participants

Methods

Results

Conclusion

Publications

Chronic widespread pain is associated with worsening frailty in European men.

Similar Datasets

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