Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi T
PROVIDER: S-EPMC4777216 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Yamaguchi Tomoya T Lu Can C Ida Lisa L Yanagisawa Kiyoshi K Usukura Jiro J Cheng Jinglei J Hotta Naoe N Shimada Yukako Y Isomura Hisanori H Suzuki Motoshi M Fujimoto Toyoshi T Takahashi Takashi T
Nature communications 20160104
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) sustains prosurvival signalling directly downstream of the lineage-survival oncogene NKX2-1/TTF-1 in lung adenocarcinoma. Here we report an unanticipated function of this receptor tyrosine kinase (RTK) as a scaffold of cavin-1 and caveolin-1 (CAV1), two essential structural components of caveolae. This kinase-independent function of ROR1 facilitates the interactions of cavin-1 and CAV1 at the plasma membrane, thereby preventing the lysos ...[more]