Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
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ABSTRACT:
SUBMITTER: Yan X
PROVIDER: S-EPMC4777353 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Publications
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Yan Xiaohui X Hu Zhongyi Z Feng Yi Y Hu Xiaowen X Yuan Jiao J Zhao Sihai D SD Zhang Youyou Y Yang Lu L Shan Weiwei W He Qun Q Fan Lingling L Kandalaft Lana E LE Tanyi Janos L JL Li Chunsheng C Yuan Chao-Xing CX Zhang Dongmei D Yuan Huiqing H Hua Keqin K Lu Yiling Y Katsaros Dionyssios D Huang Qihong Q Montone Kathleen K Fan Yi Y Coukos George G Boyd Jeff J Sood Anil K AK Rebbeck Timothy T Mills Gordon B GB Dang Chi V CV Zhang Lin L
Cancer cell 20151001 4
The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas. Our results suggest that the expression and dysregulation of lncRNAs are highly cancer type specific compared with protein-coding genes. Using the integrative data generated by this analysis, we prese ...[more]
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