Comparison of Early Changes in Ocular Surface and Inflammatory Mediators between Femtosecond Lenticule Extraction and Small-Incision Lenticule Extraction.

ABSTRACT: PURPOSE:To evaluate the short-term changes in ocular surface measures and tear inflammatory mediators after femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) procedures. METHODS:Eighteen subjects (18 eyes) underwent FLEx and 23 subjects (23 eyes) underwent SMILE in this single-center and prospective study. Central corneal sensitivity, Schirmer I test (SIT), noninvasive tear breakup time (NI-TBUT), tear meniscus height, corneal fluorescein (FL) staining, and ocular surface disease index (OSDI) were assessed in all patients. Concentrations of interleukin-1? (IL-1?), tumor necrosis factor-? (TNF-?), nerve growth factor (NGF), interferon-? (IFN-?), transforming growth factor-?1 (TGF-?1) and matrix metalloproteinase-9 (MMP-9) in collected tears were measured by multiplex antibody microarray. RESULTS:Central corneal sensitivity was reduced in both groups, but the scores in the SMILE group were higher than those in the FLEx group at all time points postoperatively (P<0.01). Lower FL scores and longer NI-BUT were observed in the SMILE group 1 week after surgery (P<0.05). OSDI scores in both groups increased rapidly at 1 day and 1 week postoperatively, then returned to their preoperative levels within 1 month (P<0.05). There were no significant differences in SIT or tear meniscus height between the two groups. Lower and faster recovery of tear NGF, TGF-?1 and IL-1? concentration were found in the SMILE group compared to the FLEx group postoperatively. No significant difference was found in tear TNF-?, IFN-? and MMP-9 for either group before or after surgery. Tear NGF, TGF-?1 and IL-1? show a correlation with ocular surface changes after FLEx or SMILE surgery. CONCLUSION:SMILE has superiority over FLEx in early ocular surface changes and NGF, TGF-?1 and IL-1? may contribute to the process of ocular surface recovery. TRIAL REGISTRATION:ClinicalTrials.gov NCT02540785.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC4777367 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature