Ontology highlight
ABSTRACT:
SUBMITTER: Oudin MJ
PROVIDER: S-EPMC4777680 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Oudin Madeleine J MJ Hughes Shannon K SK Rohani Nazanin N Moufarrej Mira N MN Jones Joan G JG Condeelis John S JS Lauffenburger Douglas A DA Gertler Frank B FB
Clinical & experimental metastasis 20151217 3
Several functionally distinct isoforms of the actin regulatory Mena are produced by alternative splicing during tumor progression. Forced expression of the Mena(INV) isoform drives invasion, intravasation and metastasis. However, the abundance and distribution of endogenously expressed Mena(INV) within primary tumors during progression remain unknown, as most studies to date have only assessed relative mRNA levels from dissociated tumor samples. We have developed a Mena(INV) isoform-specific mon ...[more]