Ontology highlight
ABSTRACT:
SUBMITTER: Weber AR
PROVIDER: S-EPMC4778062 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Weber Alain R AR Krawczyk Claudia C Robertson Adam B AB Kuśnierczyk Anna A Vågbø Cathrine B CB Schuermann David D Klungland Arne A Schär Primo P
Nature communications 20160302
Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically established and maintained by DNA methyltransferases and demethylases. Molecular mechanisms of active DNA demethylation began to surface only recently with the discovery of the 5-methylcytosine (5mC)-directed hydroxylase and base excision activities of ten-eleven translocation (TET) proteins and thymine DNA glycosylase (TDG). This implicated a pathway operating through oxidation of 5mC by TET proteins, which ...[more]