Modeling the Progression of Epithelial Leak Caused by Overdistension.
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ABSTRACT:
SUBMITTER: Hamlington KL
PROVIDER: S-EPMC4778393 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
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Modeling the Progression of Epithelial Leak Caused by Overdistension.
Hamlington Katharine L KL Ma Baoshun B Smith Bradford J BJ Bates Jason H T JH
Cellular and molecular bioengineering 20160119 1
Mechanical ventilation is necessary for treatment of the acute respiratory distress syndrome but leads to overdistension of the open regions of the lung and produces further damage. Although we know that the excessive stresses and strains disrupt the alveolar epithelium, we know little about the relationship between epithelial strain and epithelial leak. We have developed a computational model of an epithelial monolayer to simulate leak progression due to overdistension and to explain previous e ...[more]
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