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Microarray analysis of microRNA expression in bone marrow-derived progenitor cells from mice with type 2 diabetes.

ABSTRACT: Bone-marrow derived vascular precursors are an important endogenous repair reservoir for vascular repair and neovascularization [1]. Therapies of stem/progenitor cells targeting on angiogenesis are considered hopeful solutions for tissue repair and regeneration. However, the dysfunction of patient-derived progenitor cells has been implicated in diabetes [2], which limited the efficacy of autologous cell therapies in the clinic [3,4]. MicroRNAs are important gene regulators whose functions remain largely unknown. In this project we reported the different microRNA expression profiles in bone marrow-derived progenitor cells from type 2 diabetic mice and their normal controls using microRNA array analysis. All microarray data are available at the Gene Expression Omnibus (GEO) at NCBI (http://www.ncbi.nlm.nih.gov/geo), under accession number GSE72616.

SUBMITTER: Wang JM

PROVIDER: S-EPMC4778603 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Microarray analysis of microRNA expression in bone marrow-derived progenitor cells from mice with type 2 diabetes.

Wang Jie-Mei JM Zhang Kezhong K

Genomics data 20151123

Bone-marrow derived vascular precursors are an important endogenous repair reservoir for vascular repair and neovascularization [1]. Therapies of stem/progenitor cells targeting on angiogenesis are considered hopeful solutions for tissue repair and regeneration. However, the dysfunction of patient-derived progenitor cells has been implicated in diabetes [2], which limited the efficacy of autologous cell therapies in the clinic [3,4]. MicroRNAs are important gene regulators whose functions remain ...[more]

PMID: 26981370

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