Dabrafenib in metastatic melanoma: a monocentric 'real life' experience.
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ABSTRACT:
SUBMITTER: Cocorocchio E
PROVIDER: S-EPMC4778691 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Dabrafenib in metastatic melanoma: a monocentric 'real life' experience.
Cocorocchio E E Gandini S S Alfieri S S Battaglia A A Pennacchioli E E Tosti G G Spadola G G Barberis M M Leo M Di MD Riviello C C Pala L L Intelisano A A Martinoli C C Ferrucci P F PF
Ecancermedicalscience 20160303
Dabrafenib is a potent BRAF-kinase inhibitor. Its activity was evaluated on 40 consecutive metastatic melanoma patients (pts) harboring the V600BRAF mutations. Dabrafenib was administered orally at the dosage of 150 mg b.i.d. daily. ORR was 82%, with 7% CR, 62% PR, 13% SD and 18% PD. The median PFS and OS were seven and 17 months, respectively (median follow-up: 8.5 months). Increased risk of progression was found in pts with elevated LDH, ECOG PS >1 and more than two metastatic sites. Grade 3-4 ...[more]
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