Ontology highlight
ABSTRACT:
SUBMITTER: Hackler L
PROVIDER: S-EPMC4778904 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Hackler László L Ózsvári Béla B Gyuris Márió M Sipos Péter P Fábián Gabriella G Molnár Eszter E Marton Annamária A Faragó Nóra N Mihály József J Nagy Lajos István LI Szénási Tibor T Diron Andrea A Párducz Árpád Á Kanizsai Iván I Puskás László G LG
PloS one 20160304 3
C-150 a Mannich-type curcumin derivative, exhibited pronounced cytotoxic effects against eight glioma cell lines at micromolar concentrations. Inhibition of cell proliferation by C-150 was mediated by affecting multiple targets as confirmed at transcription and protein level. C-150 effectively reduced the transcription activation of NFkB, inhibited PKC-alpha which are constitutively over-expressed in glioblastoma. The effects of C-150 on the Akt/ Notch signaling were also demonstrated in a Droso ...[more]