Overcoming Challenges in Engineering the Genetic Code.
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ABSTRACT:
SUBMITTER: Lajoie MJ
PROVIDER: S-EPMC4779434 | biostudies-literature | 2016 Feb
REPOSITORIES: biostudies-literature
Publications
Overcoming Challenges in Engineering the Genetic Code.
Lajoie M J MJ Söll D D Church G M GM
Journal of molecular biology 20150905 5 Pt B
Withstanding 3.5 billion years of genetic drift, the canonical genetic code remains such a fundamental foundation for the complexity of life that it is highly conserved across all three phylogenetic domains. Genome engineering technologies are now making it possible to rationally change the genetic code, offering resistance to viruses, genetic isolation from horizontal gene transfer, and prevention of environmental escape by genetically modified organisms. We discuss the biochemical, genetic, an ...[more]
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