Ontology highlight
ABSTRACT:
SUBMITTER: Xiong Y
PROVIDER: S-EPMC4779695 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Xiong Yanbao Y Ahmad Sarwat S Iwami Daiki D Brinkman C Colin CC Bromberg Jonathan S JS
Journal of immunology (Baltimore, Md. : 1950) 20160215 6
T-bet is essential for natural regulatory T cells (nTreg) to regulate Th1 inflammation, but whether T-bet controls other Treg functions after entering the inflammatory site is unknown. In an islet allograft model, T-bet(-/-) nTreg, but not induced Treg, failed to prolong graft survival as effectively as wild-type Treg. T-bet(-/-) nTreg had no functional deficiency in vitro but failed to home from the graft to draining lymph nodes (dLN) as efficiently as wild type. T-bet regulated expression of a ...[more]