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Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans.


ABSTRACT: BACKGROUND:African Americans have a higher risk of developing lung cancer than European Americans. Previous studies suggested that certain circulating cytokines were associated with lung cancer. We hypothesized that variations in serum cytokine levels exist between African Americans and European Americans, and increased circulating cytokine levels contribute to lung cancer differently in the two races. METHODS:Differences in 10 serum cytokine levels, IL1?, IL4, IL5, IL6, IL8, IL10, IL12, granulocyte macrophage colony-stimulating factor, IFN?, and TNF?, between 170 African-American and 296 European-American controls from the National Cancer Institute-Maryland (NCI-MD) case-control study were assessed. Associations of the serum cytokine levels with lung cancer were analyzed. Statistically significant results were replicated in the prospective Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and the Wayne State University Karmanos Cancer Institute case-control study. RESULTS:Six cytokines, IL4, IL5, IL8, IL10, IFN?, and TNF?, were significantly higher among European-American as compared with African-American controls. Elevated IL6 and IL8 levels were associated with lung cancer among both races in all three studies. Elevated IL1?, IL10, and TNF? levels were associated with lung cancer only among African Americans. The association between elevated TNF? levels and lung cancer among European Americans was significant after adjustment for additional factors. CONCLUSIONS:Serum cytokine levels vary by race and might contribute to lung cancer differently between African Americans and European Americans. IMPACT:Future work examining risk prediction models of lung cancer can measure circulating cytokines to accurately characterize risk within racial groups.

SUBMITTER: Pine SR 

PROVIDER: S-EPMC4779723 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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Differential Serum Cytokine Levels and Risk of Lung Cancer Between African and European Americans.

Pine Sharon R SR   Mechanic Leah E LE   Enewold Lindsey L   Bowman Elise D ED   Ryan Bríd M BM   Cote Michele L ML   Wenzlaff Angela S AS   Loffredo Christopher A CA   Olivo-Marston Susan S   Chaturvedi Anil A   Caporaso Neil E NE   Schwartz Ann G AG   Harris Curtis C CC  

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20151228 3


<h4>Background</h4>African Americans have a higher risk of developing lung cancer than European Americans. Previous studies suggested that certain circulating cytokines were associated with lung cancer. We hypothesized that variations in serum cytokine levels exist between African Americans and European Americans, and increased circulating cytokine levels contribute to lung cancer differently in the two races.<h4>Methods</h4>Differences in 10 serum cytokine levels, IL1β, IL4, IL5, IL6, IL8, IL10  ...[more]

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