Ontology highlight
ABSTRACT:
SUBMITTER: Digby GJ
PROVIDER: S-EPMC4780333 | biostudies-literature | 2010 Aug
REPOSITORIES: biostudies-literature
Digby Gregory J GJ Shirey Jana K JK Conn P Jeffrey PJ
Molecular bioSystems 20100625 8
Muscarinic acetylcholine receptors (mAChRs) represent exciting therapeutic targets for the treatment of multiple CNS disorders. The high degree of conservation of amino acids comprising the orthosteric acetylcholine (ACh) binding site between individual mAChR subtypes has hindered the development of subtype-selective compounds that bind to this site. As a result, many academic and industry researchers are now focusing on developing allosteric activators of mAChRs including both positive alloster ...[more]