Dissecting the Genetic Susceptibility to Graves' Disease in a Cohort of Patients of Italian Origin.

ABSTRACT: Graves' disease (GD) is an autoimmune oligogenic disorder with a strong hereditary component. Several GD susceptibility genes have been identified and confirmed during the last two decades. However, there are very few studies that evaluated susceptibility genes for GD in specific geographic subsets. Previously, we mapped a new locus on chromosome 3q that was unique to GD families of Italian origin. In the present study, we used association analysis of single-nucleotide polymorphism (SNPs) at the 3q locus in a cohort of GD patients of Italian origin in order to prioritize the best candidates among the known genes in this locus to choose the one(s) best supported by the association. DNA samples were genotyped using the Illumina GoldenGate genotyping assay analyzing 690 SNP in the linked 3q l

SUBMITTER: Lombardi A 

PROVIDER: S-EPMC4781855 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature