Elevation of Circulating miR-210-3p in High-Altitude Hypoxic Environment.

ABSTRACT:

Background

The induction of miR-210-3p, a master hypoxamir, is a consistent feature of the hypoxic response in both normal and malignant cells. However, whether miR-210-3p acts as a circulating factor in response to a hypoxic environment remains unknown. The current study aimed to examine the effect of a high-altitude hypoxic environment on circulating miR-210-3p.

Methods

We examined and compared the levels of miR-210-3p using TaqMan-based qRT-PCR in both peripheral blood cells and plasma from 84 ethnic Chinese Tibetans residing at 3560 m, 46 newly arrived migrant Han Chinese (Tibet Han) and 82 Han Chinese residing at 8.9 m (Nanjing Han). Furthermore, we analyzed the correlations of miR-210-3p with hematological indices.

Results

The relative concentrations of miR-210-

SUBMITTER: Yan Y 

PROVIDER: S-EPMC4781857 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature