TEMPOL increases NAD(+) and improves redox imbalance in obese mice.
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ABSTRACT:
SUBMITTER: Yamato M
PROVIDER: S-EPMC4781928 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
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TEMPOL increases NAD(+) and improves redox imbalance in obese mice.
Yamato Mayumi M Kawano Kimika K Yamanaka Yuki Y Saiga Misako M Yamada Ken-Ichi K
Redox biology 20160226
Continuous energy conversion is controlled by reduction-oxidation (redox) processes. NAD(+) and NADH represent an important redox couple in energy metabolism. 4-Hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) is a redox-cycling nitroxide that promotes the scavenging of several reactive oxygen species (ROS) and is reduced to hydroxylamine by NADH. TEMPOL is also involved in NAD(+) production in the ascorbic acid-glutathione redox cycle. We utilized the chemical properties of TEMPOL to inves ...[more]
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