Ontology highlight
ABSTRACT:
SUBMITTER: Schroyen M
PROVIDER: S-EPMC4782518 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Schroyen Martine M Eisley Christopher C Koltes James E JE Fritz-Waters Eric E Choi Igseo I Plastow Graham S GS Guan Leluo L Stothard Paul P Bao Hua H Kommadath Arun A Reecy James M JM Lunney Joan K JK Rowland Robert R R RR Dekkers Jack C M JC Tuggle Christopher K CK
BMC genomics 20160308
<h4>Background</h4>A region on Sus scrofa chromosome 4 (SSC4) surrounding single nucleotide polymorphism (SNP) marker WUR10000125 (WUR) has been reported to be strongly associated with both weight gain and serum viremia in pigs after infection with PRRS virus (PRRSV). A proposed causal mutation in the guanylate binding protein 5 gene (GBP5) is predicted to truncate the encoded protein. To investigate transcriptional differences between WUR genotypes in early host response to PRRSV infection, an ...[more]