Disease risk estimation by combining case-control data with aggregated information on the population at risk.
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ABSTRACT:
SUBMITTER: Chang X
PROVIDER: S-EPMC4782587 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Publications
Disease risk estimation by combining case-control data with aggregated information on the population at risk.
Chang Xiaohui X Waagepetersen Rasmus R Yu Herbert H Ma Xiaomei X Holford Theodore R TR Wang Rong R Guan Yongtao Y
Biometrics 20141028 1
We propose a novel statistical framework by supplementing case-control data with summary statistics on the population at risk for a subset of risk factors. Our approach is to first form two unbiased estimating equations, one based on the case-control data and the other on both the case data and the summary statistics, and then optimally combine them to derive another estimating equation to be used for the estimation. The proposed method is computationally simple and more efficient than standard ...[more]
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