Functional neuroanatomy of spatial sound processing in Alzheimer's disease.
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ABSTRACT:
SUBMITTER: Golden HL
PROVIDER: S-EPMC4782736 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Functional neuroanatomy of spatial sound processing in Alzheimer's disease.
Golden Hannah L HL Agustus Jennifer L JL Nicholas Jennifer M JM Schott Jonathan M JM Crutch Sebastian J SJ Mancini Laura L Warren Jason D JD
Neurobiology of aging 20151219
Deficits of auditory scene analysis accompany Alzheimer's disease (AD). However, the functional neuroanatomy of spatial sound processing has not been defined in AD. We addressed this using a "sparse" fMRI virtual auditory spatial paradigm in 14 patients with typical AD in relation to 16 healthy age-matched individuals. Sound stimulus sequences discretely varied perceived spatial location and pitch of the sound source in a factorial design. AD was associated with loss of differentiated cortical p ...[more]
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