Ontology highlight
ABSTRACT:
SUBMITTER: Godin LM
PROVIDER: S-EPMC4783067 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Godin Lindsay M LM Sandri Brian J BJ Wagner Darcy E DE Meyer Carolyn M CM Price Andrew P AP Akinnola Ifeolu I Weiss Daniel J DJ Panoskaltsis-Mortari Angela A
PloS one 20160308 3
The lung changes functionally and structurally with aging. However, age-related effects on the extracellular matrix (ECM) and corresponding effects on lung cell behavior are not well understood. We hypothesized that ECM from aged animals would induce aging-related phenotypic changes in healthy inoculated cells. Decellularized whole organ scaffolds provide a powerful model for examining how ECM cues affect cell phenotype. The effects of age on ECM composition in both native and decellularized mou ...[more]