Ontology highlight
ABSTRACT:
SUBMITTER: Boelen L
PROVIDER: S-EPMC4783075 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Boelen Lies L O'Neill Patrick K PK Quigley Kathryn J KJ Reynolds Catherine J CJ Maillere Bernard B Robinson John H JH Lertmemongkolchai Ganjana G Altmann Daniel M DM Boyton Rosemary J RJ Asquith Becca B
PLoS computational biology 20160308 3
Activation of CD4+ T cells requires the recognition of peptides that are presented by HLA class II molecules and can be assessed experimentally using the ELISpot assay. However, even given an individual's HLA class II genotype, identifying which class II molecule is responsible for a positive ELISpot response to a given peptide is not trivial. The two main difficulties are the number of HLA class II molecules that can potentially be formed in a single individual (3-14) and the lack of clear pept ...[more]