Ontology highlight
ABSTRACT:
SUBMITTER: Alepee N
PROVIDER: S-EPMC4783151 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Alépée Natalie N Bahinski Anthony A Daneshian Mardas M De Wever Bart B Fritsche Ellen E Goldberg Alan A Hansmann Jan J Hartung Thomas T Haycock John J Hogberg Helena H Hoelting Lisa L Kelm Jens M JM Kadereit Suzanne S McVey Emily E Landsiedel Robert R Leist Marcel M Lübberstedt Marc M Noor Fozia F Pellevoisin Christian C Petersohn Dirk D Pfannenbecker Uwe U Reisinger Kerstin K Ramirez Tzutzuy T Rothen-Rutishauser Barbara B Schäfer-Korting Monika M Zeilinger Katrin K Zurich Marie-Gabriele MG
ALTEX 20140714 4
Integrated approaches using different in vitro methods in combination with bioinformatics can (i) increase the success rate and speed of drug development; (ii) improve the accuracy of toxicological risk assessment; and (iii) increase our understanding of disease. Three-dimensional (3D) cell culture models are important building blocks of this strategy which has emerged during the last years. The majority of these models are organotypic, i.e., they aim to reproduce major functions of an organ or ...[more]