Mechanisms and Dynamics of Protein Acetylation in Mitochondria.
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ABSTRACT:
SUBMITTER: Baeza J
PROVIDER: S-EPMC4783225 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Mechanisms and Dynamics of Protein Acetylation in Mitochondria.
Baeza Josue J Smallegan Michael J MJ Denu John M JM
Trends in biochemical sciences 20160125 3
Reversible protein acetylation is a major regulatory mechanism for controlling protein function. Through genetic manipulations, dietary perturbations, and new proteomic technologies, the diverse functions of protein acetylation are coming into focus. Protein acetylation in mitochondria has taken center stage, revealing that 63% of mitochondrially localized proteins contain lysine acetylation sites. We summarize the field and discuss salient topics that cover spurious versus targeted acetylation, ...[more]
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