Ontology highlight
ABSTRACT:
SUBMITTER: Yuan S
PROVIDER: S-EPMC4783701 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Yuan Shuofeng S Chu Hin H Singh Kailash K Zhao Hanjun H Zhang Ke K Kao Richard Y T RY Chow Billy K C BK Zhou Jie J Zheng Bo-Jian BJ
Scientific reports 20160309
The RNA-dependent RNA polymerase of influenza A virus comprises conserved and independently-folded subdomains with defined functionalities. The N-terminal domain of the PA subunit (PA(N)) harbors the endonuclease function so that it can serve as a desired target for drug discovery. To identify a class of anti-influenza inhibitors that impedes PA(N) endonuclease activity, a screening approach that integrated the fluorescence resonance energy transfer based endonuclease inhibitory assay with the D ...[more]