Ontology highlight
ABSTRACT:
SUBMITTER: Kelly C
PROVIDER: S-EPMC4784727 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Kelly Christabel C Swadling Leo L Brown Anthony A Capone Stefania S Folgori Antonella A Salio Mariolina M Klenerman Paul P Barnes Eleanor E
European journal of immunology 20141030 1
Viral diversity is a challenge to the development of a hepatitis C virus (HCV) vaccine. Following vaccination of humans with adenoviral vectors, we determined the capacity of T cells to target common viral variants at immundominant epitopes ex vivo. We identified two major variants for epitopes NS3(1073) and NS3(1446), and multiple variants for epitope NS3(1406) that occurred in >5% of genotype 1 and 3 sequences at a population level. Cross-reactivity of vaccine-induced T cells was determined us ...[more]