Pathway-Based Genomics Prediction using Generalized Elastic Net.
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ABSTRACT:
SUBMITTER: Sokolov A
PROVIDER: S-EPMC4784899 | biostudies-literature | 2016 Mar
REPOSITORIES: biostudies-literature
Publications
Pathway-Based Genomics Prediction using Generalized Elastic Net.
Sokolov Artem A Carlin Daniel E DE Paull Evan O EO Baertsch Robert R Stuart Joshua M JM
PLoS computational biology 20160309 3
We present a novel regularization scheme called The Generalized Elastic Net (GELnet) that incorporates gene pathway information into feature selection. The proposed formulation is applicable to a wide variety of problems in which the interpretation of predictive features using known molecular interactions is desired. The method naturally steers solutions toward sets of mechanistically interlinked genes. Using experiments on synthetic data, we demonstrate that pathway-guided results maintain, and ...[more]
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